Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
最佳迷你剧/电影：《美国罪案故事：公诉辛普森》(“The People v. O. J. Simpson: American Crime Story”, FX)
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
“These kinds of questions are really front and center, even though they’re not necessarily verbalized.”
Astronomers confirmed a key part of Einstein’s general theory of relativity in 2016 when they announced that the LIGO array had detected gravitational waves released by the collision of two black holes. The researchers won a Nobel Prize for the discovery. But they’re not done: In October, scientists announced the finding of two dead stars colliding — not only hearing the ripples in space-time they made, but confirming the event visually with powerful telescopes. Collisions of neutron stars are believed to be the source of all heavy metals in the universe, including gold and silver, and the detection by LIGO helps verify accepted explanations of how the chemistry of the universe formed.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
9.The Company Isn't Doing Well
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
It seems safe to predict lots more noise and very little progress for the rest of 2017. And that will continue to be a damaging combination for business and the UK economy.
节目6 小品《想跳就跳》，潘长江 蔡明 郭丰周
Hunger Games star Jennifer Lawrence on Tuesday topped a Forbes magazine list of the world’s highest-paid actress for the second straight year, earning some $46 million, followed by Melissa McCarthy.
Trends and targets in antiviral phototherapy
Mr Talbot notes that regulators in Japan are encouraging fee-based sales with a new fiduciary code and other measures that will play to the low-cost appeal of ETFs.
Mr Trump is almost a textbook demagogue.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
All three of the big worldwide financial bubbles that have blow up in the last three decades have 'been fueled by the Fed keeping policy rates below the nominal growth rate of the economy far too long, ' says global strategist Kit Juckes of the French bank Societe Generale.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
A New Year greeting to cheer you from your daughters.
“Why do we keep getting so many record-warm years?” Dr. Schmidt asked in an interview. “It’s because the planet is warming. The basic issue is the long-term trend, and it is not going away.”
Diagnostic technologies for COVID-19: a review
Economists had likewise expected year-to-date urban fixed asset investment, a rough proxy for long-term spending, to remain at September’s level of 8.2 per cent year on year growth.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Rounding out the top three is Fleetwood Mac at $59.5 million. Though the band contains three men, it also boasts two high-profile ladies—Stevie Nicks and the recently-returned Christine McVie—rendering the group eligible for this list. Its On With The Show tour included 86 concerts during our scoring period, grossing well over $1 million per city.
The three bubbles: The Asian Bubble in the early '90s, Dot-com Bubble of the late '90s and what Juckes calls the Great Big Credit Bubble that triggered the 2008 Wall Street meltdown.
"Sure, there are only whites in the stadium. It comes down to money," said Ana Beatriz Ferreira, a 27-year-old parking attendant in Rio de Janeiro, who is black. "Nobody I know could find affordable tickets."
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Two United States cities have seen significant increases in costs, with Los Angeles rising 19 places to enter the top 10.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Some hits have gone so far over the top they should be winded, yet instead keep on puffing gusts of hot air, including “Downton Abbey,” “Scandal” and “Revenge.” A new addition on ABC, “How to Get Away With Murder” was a fun substitute, a lurid nighttime soap opera about lawbreaking defense lawyers — “Law & Disorder.”
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
2013 Rank: 14
Antiviral drug discovery: broad-spectrum drugs from nature
Strengthening the all-around improvement of government
Influenza neuraminidase: A druggable target for natural products
Making Airbnb go away might not be so easy. A recent Quinnipiac poll found that 56 percent of the responders thought New Yorkers should be allowed to rent rooms out to strangers. “We don’t want to turn into hotels, but at the same time people want to rent out their apartments sometimes,” said Paul R. Gottsegen, the president of Halstead Management Company, which manages 250 residential properties in the city.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The nearest star, Proxima Centauri, has a planet orbiting it not much bigger than Earth. Its "year" is only 11 days. But it's in the habitable zone because Proxima Centauri is a red dwarf star about 100 times fainter than the sun. And there's hot news that a similar star, 40 light years away, may have three planets in its habitable zone.
The 25 most common passwords have been released by Splashdata which makes password management applications.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
The appointment of Inga Beale to run Lloyds of London and of Mary Barra to run General Motors marked an encouraging end to 2013. Progress for women in the coming year will continue to be too little and too slow, but you should expect to see women in positions of power and influence everywhere. Even Japan is starting to try to get women into work.
The seven large brick tombs were likelyconstructed for people of wealth, the researchers said.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Referencing the American chat show host, he quipped: 'I've always wanted to meet Jay Leno,' before laughing to himself. Clearly unimpressed, Dallas Buyers Club star Jared hit back: 'Sorry, what was your name again?'But audiences seemed to pick up on the atmosphere between the two, with one viewer joking: 'Think Jared Leto got a bit paranoid about Grinder looking at him.'
Up to 10,000 copies of the film - a comedy about a fictional CIA plot to assassinate North Korean leader Kim Jong-Un - and 500,000 political leaflets are scheduled for a balloon-launch around 26 March.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
10. 《66》(Sixty Six)。刘易斯·卡尔(Lewis Klahr)把数码短片精彩地汇集在一起，以一种英雄气概的方式复制流行文化，它只在MoMA上映过一晚。但他的作品也在洛杉矶和旧金山等城市上映，所以如果你住在附近，可以去看他的下一次展映。
This journey into the mind and feelings of an 11-year-old-girl may be Pixar’s wildest adventure yet. It’s a very funny workplace sitcom (with exuberant, touching performances from Amy Poehler, Phyllis Smith, Mindy Kaling and others), an ingenious allegory of psychological development, and an almost unbearably moving and honest defense of the role of sadness in our lives. (Read the review.)
THE EFFECT OF RAPID CHANGE
The value of goods that crossed international borders last year fell 13.8 per cent in dollar terms — the first contraction since 2009 — according to the Netherlands Bureau of Economic Policy Analysis’s World Trade Monitor. Much of the slump was due to a slowdown in China and other emerging economies.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Pork and vegetable prices both dropped by more than 8 percent year-on-year.
Swyft now makes half of its money from ad campaigns like the one for Gwen Stefani. Swyft’s revenue has increased between 50% and 100% each month, Wray says. The other half comes from selling stickers—typically licensed from sports teams and entertainment brands like Shrek.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
《风骚律师》(Better Call Saul)，AMC，2月8日播出。这是文斯·吉里根(Vice Gilligan)与彼得·古尔德(Peter Gould)的《绝命毒师》的衍生剧，或许是今年冬天最受期待的新剧了。鲍勃·奥登科克(Bob Odenkirk)饰演狡猾的律师索尔·古德曼(Saul Goodman)，剧情设定在《绝命毒师》的故事发生之前，所以布莱恩·克莱斯顿(Bryan Cranston)或亚伦·保罗(Aaron Paul)至多只是客串出演而已。但观众们最喜欢的乔纳森·班克斯(Jonathan Banks)将在里面重现他在《绝命毒师》中的角色——冷静的行动执行者迈克·厄尔曼特劳特(Mike Ehrmantraut)。
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
A research team at the University of Chicago has solved this problem, producing hands that send electric signals to the brain. They've begun with monkeys as test subjects, studying the animals to see how their brains respond to touch. When outfitted with prosthetic hands that stimulate their brains that way, the monkeys respond just as though they physically touch objects themselves.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Whether or not any sort of BlackBerry-Samsung deal actually happens, the development highlights next wave of innovation (and litigation) in mobile technology: one centered on access control methods and containing corporate breachesin an increasingly mobile world.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
University officials said the letter was now on its way to him along with a T-shirt from the university.
Nearly all the entrepreneurs (93 per cent) rated their new skills as important or very important in their decision. “I understand the value of my skills without the ‘fear’ of not being employed,” said one.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Talking about wanting to kill your boss may not be that uncommon, but it does put a damper on things when said boss actually ends up murdered. When the police came to ask questions, they ended up learning that the Cranston brothers had recently resigned to ride their motorcycles cross-country. Until they could be cleared, the two men were both suspects.
Autonomous cars: Researchers are working on devices that will automatically park your car in a parking lot without you being in, or near, the car. It will also slip a note under the wipers of the car next to it with your phone number and insurance carrier in case of any scratches.
Set in 1950's London, Reynolds Woodcock is a renowned dressmaker whose fastidious life is disrupted by a young, strong-willed woman, Alma, who becomes his muse and lover.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
在苹果(Apple)的蒂姆库克(Tim Cook)支持AR后，该技术可能是更大的机遇。苹果最新操作系统及新款手机iPhone X纳入了AR技术。
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Rounding out the top three is Chrissy Teigen, 31, who joins the list for the first time after raking in $13.5 million over the past 12 month-period.
v. 构成，把 ...
7. Smart cookie oven
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
If there are nine or 10 best picture nominees, it could grab a spot. Jordan Peele's screenplay looks certain to be recognized.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
INDOORS: This house was completed around 1848 and last updated in 2008. The front door has a transom and sidelights of red glass etched with a leaf motif. The first floor has a large living room with crown molding and two fireplaces, one of which warms the formal dining area. Off the living room is a family room with raised wall paneling, a wet bar and another dining area. French doors open to a slate patio. Several rooms have views of Little Narragansett Bay.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
The price of gold has risen 15 per cent since the beginning of 2017 to trade at $1,334.78 a troy ounce.
A modular microarray imaging system for highly specific COVID-19 antibody testing
None of these conditions is in place now. Fed tightening, begun in December, has been put on hold. The federal funds rate (the interbank overnight lending rate) is estimated to be more than a percentage point below its natural level. And there have been no surprises from the Fed. Last December’s 25 basis point rise in the Fed’s policy rate, for example, was comprehensively signalled in advance.
“It’s eerie how similar this space is to CRM when Marc Benioff launched Salesforce.com,” said Mitch Harper, who co-founded the company in 2009 with co-CEO Eddie Machaalani. “The parallels are uncanny.”
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Ms Lewis urged people to contact family, neighbours or an animal shelter if they were no longer able to care for their pets.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
节目16 武术《少年中国》，赵文卓 范龙飞 侯英岗
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
The promotion of urbanization in central and western China has also attracted many members of the labor force from coastal cities in East China to inland regions, where the cost of living is much lower, Peng explained.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
She pointed to equal pay, saying it's not "just a woman's issue" but something that affects everyone. "If you have a wife, a mother, a sister, a daughter who is working and they are not being treated fairly, the whole family suffers," Clinton said.
A facile assay for rapid detection of COVID-19 antibodies
In early December, authorities announced that market circuit breakers would be introduced become effective from January 1 in an effort to limit the volatility seen during the savage, summer sell-off from June. The circuit breakers would see trading in shares, options and futures halted for 15 minutes if they fell by more than 5 per cent. On their first day of use, that first threshold was breached just after the return from the lunchbreak, prompting a 15-minute halt.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Baoneng’s raid has been bitterly resisted by Wang Shi, Vanke’s founder who has sought out white knights in a so far successful effort to retain control of the management-led company. The takeover battle fuelled a surge both in the price of Vanke’s Shenzhen-traded shares and Mr Yao’s known worth.
例如，佳士得给威尼斯艺术家弗朗西斯科·丰泰巴索(Francesco Fontebasso)在18世纪中叶创作的油画《井边的丽贝卡和埃利泽》(Rebecca and Eliezer at the Well)的最低估价为12万英镑。根据Artnet的数据，在1990年的拍卖会上，这幅令人愉快的洛可可装饰风格的油画是以28.6万英镑购得的。在12月8日的拍卖会上，它仅得到一个电话出价——11.5万英镑（不含佣金），约合17万美元。而投资者们可不认为在购买沃霍尔(Warhol)或巴斯奎特(Basquiat)的作品25年之后会损失约40%。如果一幅早期绘画大师的作品被搁置在交易商的画廊里，想转卖它就更加困难。
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
After a year of sexual harassment scandals that started in Silicon Valley and spread to just about every industry, women will try to capitalise on the momentum to push for permanent changes. And attention will focus on the plight of marginalised minorities, with so few black and Latino employees in the tech industry.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
And, men are 2.8 times more likely to use this obvious phrase than women.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
会。梅亚德是执政党革命制度党(PRI)的候选人。他主要的竞争对手是强硬的左翼领导人安德烈斯曼努埃尔洛佩斯奥夫拉多尔(Andrés Manuel López Obrador)——可以感召人群的激情演说家。梅亚德需要克服很多问题：在去年1月一夜间把油价上调20%、引发通胀飙升后，他必须说服选民自己仍然是可以信任的。他还必须证明自己是个有主见的人，而不仅仅是这届不受欢迎的政府的傀儡——在遏制猖獗的腐败和犯罪行为方面，这届政府极为失败。但是凭借强大的PRI拉票机器，他可能势不可挡。在墨西哥只有一轮选举的体制下，30%的选票可能就足以让他当选总统了。
4. Con Dao Isalsnd, Vietnam-Once the site of the infamous Con Dao prison, Vietnam's isolated archipelago of 16 islands known as the Con Dao Islands is starting to become known for its scenery and fresh seafood.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Author Anthony Horowitz has revealed the new book Trigger Mortis has been amended for modern readers and contains anti-smoking messages and for the first time an ‘outspoken’ gay friend.
Anti-HIV drug repurposing against SARS-CoV-2
Length-scale dependence of protein hydration-shell density
To put this all in a bit more perspective, the current World Cup is averaging more goals than any of the top leagues around the world averaged in 2013/14. TheNetherlands' Eredivisie was the highest scoring of the top European leagues at 3.20 and the Bundesliga was just a shade behind at 3.16. No other top European league averaged more than 2.80 last season. In theAmericas, Major League Soccer is the current pace setter at 2.89 goals per game.
The country's improved performance has notched the 17th place in "innovation quality", an indicator that looks at the caliber of universities, number of scientific publications and international patent filings.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
The 8,000 volunteers who will welcome international visitors to London 2012 have been issued with a 66-page instruction manual, covering everything from foreign etiquette to uniform care and advice on dealing with journalists. But what of the visitors themselves? Could they not do with a manual outlining the customs, manners and practicalities of the islands they are visiting? We hereby present a simple guide to UK etiquette for the 2012 Olympics.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
1. Bottoms Up Beer System
About this collection
France continues to hold the position as Germany's second largest trading partner in 2016, according to data from DIHK.
The 8 per cent year-on-year drop in profits last month compares with 4.2 per cent in November and is the biggest since the current data series began in late 2011, figures released on Tuesday showed.